Regular physical exercise has several beneficial effects on overall health. As obesity rates continue to rise, the prevalence of associated comorbidities including T2D and CVD increase concomitantly ( 7) overweight people are twice as likely, and severely obese people are ten times more likely to develop cardiovascular diseases than individuals of a healthy weight ( 8). Obesity is associated with many adverse health effects, including increased risks of cardiovascular disease (CVD), type 2 diabetes (T2D), certain cancers, and death ( 2– 6). Obesity and its associated co-morbidities are increasing at rapid rates across the United States and worldwide ( 1). In this review we will discuss the mechanisms through which exercise promotes cardiovascular health.
Some benefits of exercise include enhanced mitochondrial function, restoration and improvement of vasculature, and the release of myokines from skeletal muscle that preserve or augment cardiovascular function. Exercise prevents both the onset and development of cardiovascular disease and is an important therapeutic tool to improve outcomes for patients with cardiovascular disease. Physical exercise results in numerous health benefits and is an important tool to combat obesity and its co-morbidities, including cardiovascular disease. Obesity is a complex disease that affects whole body metabolism and is associated with an increased risk of cardiovascular disease (CVD) and Type 2 diabetes (T2D). Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, United States Department of Physiology and Cell Biology, Dorothy M.
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